Wisconsin Alzheimer's Disease Research Center
J5/156M, Clinical Science Center
600 Highland Avenue
Madison, WI, 53792
My research focuses on clarifying how alterations in the brain and other biomolecules (such as cerebrospinal fluid β-amyloid) place some cognitively-normal individuals on a pernicious trajectory that culminates in probable Alzheimer’s disease. In this context, I am also interested in discovering new knowledge concerning the modulation of the link between brain changes and cognitive decline by both modifiable (e.g., cognitively-stimulating activities, physical exercise) and non-modifiable (e.g., genetic vulnerability) factors.
This program of research leverages the broad state-of-the-art resources available at the University of Wisconsin-Madison (UW) including the Wisconsin Alzheimer’s Disease Research Center, the Wisconsin Registry for Alzheimer’s Prevention, the Waisman Laboratory for Brain Imaging, and the UW Biotechnology Center. It involves partnerships with colleagues in neuroradiology, medical physics, exercise science, biostatistics, computer science, genetic epidemiology, and clinical chemistry; and has been generously supported by the NIA, the American Federation for Aging Research (AFAR), the John A. Hartford Foundation, the Alzheimer’s Association, and the UW Institute for Clinical and Translational Research.