Biography:

I am interested in developing and applying advanced MRI imaging techniques to characterize early changes in Alzheimer’s Disease brain. Major research focus on using multimodal imaging approach including cerebral blood flow, brain metabolism and amyloid images to understand the pathophysiological changes associated with AD risks.

Alzheimer’s association link

Publications:

• Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults

  April 3, 2013

• Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer’s disease

  January 1, 2013

• Low cerebral blood flow is associated with lower memory function in metabolic syndrome.

  January 1, 2013

• Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults

  August 1, 2012

• Longitudinal volumetric changes following traumatic brain injury: A tensor based morphometry study

  May 14, 2012

• Current status and future perspectives of magnetic resonance high-field imaging: a summary

  May 1, 2012

• A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches

  April 1, 2012

• Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults

  February 1, 2012

• Medial Prefrontal Functional Connectivity - Relation to Memory Self-appraisal Accuracy in Older Adults with and without Memory Disorders

  January 1, 2012

• Effects of Atorvastatin on Cerebral Blood Flow in Middle-Aged Adults at Risk for Alzheimer's Disease: A Pilot Study

  January 1, 2012

• Rate of 6-[18F]fluoro-L-dopa uptake decline in striatal subregions in Parkinson’s disease

  March 26, 2011

• Predictive Markers for AD in a Multi-Modality Framework: An Analysis of MCI Progression in the ADNI Population

  March 15, 2011

• A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease

  January 1, 2011

• Effects of Hypoperfusion in Alzheimer's Disease

  January 1, 2011

• Effects of Hypoperfusion in Alzheimer's Disease

  January 1, 2011

• Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys

  July 1, 2010

• Effects of aging and calorie restriction on white matter in rhesus macaques.

  June 10, 2010

• A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys

  June 9, 2010

• White Matter in Aging and Cognition: A Cross-sectional Study of Microstructure in Adults Aged Eighteen to Eighty-Three

  May 1, 2010

• Reliability and Precision of Pseudo-continuous Arterial Spin Labeling Perfusion MRI on 3.0 T and Comparison with 15O-water PET in Elderly Subjects at Risk for Alzheimer’s Disease

  January 1, 2010

• Midlife predictors of Alzheimer's disease

  December 29, 2009

• Spatially augmented LPboosting for AD classification with evaluations on the ADNI dataset

  May 27, 2009

• The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory

  February 1, 2009

• Atorvastatin Therapy is Associated with Greater and Faster Cerebral Hemodynamic Response

  June 1, 2008