Biography:

Dr. Asthana is interested in clinical psychopharmacology and neuroendocrinology of gonadal steroids and cholinergic drugs in Alzheimer’s disease and healthy aging

1. Cognitive and neuroendocrine effects of estrogen and testosterone administration in Alzheimer’s disease and healthy aging.
2. Potential beneficial effects of estrogen and testosterone treatment on performance-based measures of independent living skills for healthy older adults as well as those with Alzheimer’s disease.
3. Identification of biological markers for therapeutic responsivity to estrogen for women with Alzheimer’s disease.
4. Evaluation of therapeutic efficacy of raloxifene, a selective estrogen receptor modulator (SERM), in subjects with Alzheimer’s disease.
5. Cholinergic drugs: Clinical psychopharmacology studies in Alzheimer’s disease.
6. Clinical pharmacokinetics and neuroendocrinology of cholinergic drugs in subjects with AD.

Publications:

• Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer’s disease

  January 1, 2013

• Low cerebral blood flow is associated with lower memory function in metabolic syndrome.

  January 1, 2013

• Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults

  February 1, 2012

• Medial Prefrontal Functional Connectivity - Relation to Memory Self-appraisal Accuracy in Older Adults with and without Memory Disorders

  January 1, 2012

• The Effects of Ramipril in Individuals at Risk for Alzheimer's Disease: Results of a Pilot Clinical Trial

  January 1, 2012

• Effects of Atorvastatin on Cerebral Blood Flow in Middle-Aged Adults at Risk for Alzheimer's Disease: A Pilot Study

  January 1, 2012

• The Effect of TOMM40 Poly-T length on Gray Matter Volume and Cognition in Middle-Aged Persons with APOE ε3/ε3 Genotype

  March 1, 2011

• NSAIDs may protect against age-related brain atrophy

  September 3, 2010

• White matter is altered with parental family history of Alzheimer’s disease

  September 1, 2010

• Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults

  July 15, 2010

• Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment

  January 1, 2010

• Midlife predictors of Alzheimer's disease

  December 29, 2009

• The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory

  February 1, 2009