Biography:

Dr. Johnson is a clinical neuropsychologist with research interests in brain function in Alzheimers Disease and related disorders. Current projects focus on A) the neurobiological and psychological processes that affect memory; B) early detection of Alzheimers Disease with multi-modal imaging including amyloid imaging; C) machine learning based multi-modal imaging markers of AD; D) enriching clinical trials and improving trial design with multi-kernel machine learning to speed the discovery of effective treatments for AD.

Professor in the Dept of Medicine, Section of Geriatrics and Gerontology and affiliated with the following departments and centers on campus at the University of Wisconsin-Madison

Geriatric Research Education and Clinical Center (GRECC), Wm. S. Middleton Memorial Veterans Hospital
Wisconsin Alzheimer’s Disease Research Center
Wisconsin Alzheimer’s Institute
Wisconsin Institute on Aging
Neuroscience Training Program
Department of Psychology

Publications:

• Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study

  May 1, 2013

• Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults

  April 3, 2013

• White matter microstructural integrity and executive function in Parkinson’s disease

  March 19, 2013

• Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques

  March 6, 2013

• Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults

  February 1, 2013

• Low cerebral blood flow is associated with lower memory function in metabolic syndrome.

  January 1, 2013

• Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer’s disease

  December 12, 2012

• Q-MKL: Matrix-induced Regularization in Multi-Kernel Learning with Applications to Neuroimaging

  December 3, 2012

• Wavelet based multi-scale shape features on arbitrary surfaces for cortical thickness discrimination

  December 1, 2012

• Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys

  November 8, 2012

• Longitudinal volumetric changes following traumatic brain injury: A tensor based morphometry study

  November 1, 2012

• Effects of Atorvastatin on Cerebral Blood Flow in Middle-Aged Adults at Risk for Alzheimer's Disease: A Pilot Study

  October 1, 2012

• Longitudinal diffusion tensor imaging and neuropsychological correlates in traumatic brain injury patients

  May 20, 2012

• Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys

  May 6, 2012

• Head size may modify the impact of white matter lesions on dementia

  May 1, 2012

• A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches

  April 1, 2012

• Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults

  February 1, 2012

• MKL-Based Sample Enrichment and Customized Outcomes Enable Smaller AD Clinical Trials

  January 1, 2012

• Medial Prefrontal Functional Connectivity - Relation to Memory Self-appraisal Accuracy in Older Adults with and without Memory Disorders

  January 1, 2012

• The Effects of Ramipril in Individuals at Risk for Alzheimer's Disease: Results of a Pilot Clinical Trial

  January 1, 2012

• Topology based Kernels with Application to Inference Problems in Alzheimer’s disease

  October 1, 2011

• A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease

  September 1, 2011

• A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease

  September 1, 2011

• Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys

  July 1, 2011

• Rate of 6-[18F]fluoro-L-dopa uptake decline in striatal subregions in Parkinson’s disease

  March 26, 2011

• Predictive Markers for AD in a Multi-Modality Framework: An Analysis of MCI Progression in the ADNI Population

  March 15, 2011

• The Effect of TOMM40 Poly-T length on Gray Matter Volume and Cognition in Middle-Aged Persons with APOE ε3/ε3 Genotype

  March 1, 2011

• Effects of Hypoperfusion in Alzheimer's Disease

  January 1, 2011

• Effects of Hypoperfusion in Alzheimer's Disease

  January 1, 2011

• Functional Magnetic Resonance Imaging of Swallowing: From Neurophysiology to Neuroplasticity

  January 1, 2011

• Mapping the structural brain changes in Alzheimer's disease: the independent contribution of two imaging modalities

  January 1, 2011

• Swallowing Intentional off-state in aging and Alzheimer’s Disease: A preliminary study

  January 1, 2011

• NSAIDs may protect against age-related brain atrophy

  September 3, 2010

• White matter is altered with parental family history of Alzheimer’s disease

  September 1, 2010

• Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys

  August 4, 2010

• Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults

  July 15, 2010

• Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys

  July 1, 2010

• Effects of aging and calorie restriction on white matter in rhesus macaques.

  June 10, 2010

• A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys

  June 9, 2010

• White Matter in Aging and Cognition: A Cross-sectional Study of Microstructure in Adults Aged Eighteen to Eighty-Three

  May 1, 2010

• Reliability and Precision of Pseudo-continuous Arterial Spin Labeling Perfusion MRI on 3.0 T and Comparison with 15O-water PET in Elderly Subjects at Risk for Alzheimer’s Disease

  April 1, 2010

• Rhesus Macaque Brain Morphometry: A Methodological Comparison of Voxel-Wise Approaches

  March 1, 2010

• Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer’s disease

  January 1, 2010

• Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment

  January 1, 2010

• Midlife predictors of Alzheimer's disease

  December 29, 2009

• Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

  July 10, 2009

• Spatially augmented LPboosting for AD classification with evaluations on the ADNI dataset

  May 27, 2009

• Posterior Cingulate and Lateral Parietal Gray Matter Volume in Older Adults with Depressive Symptoms

  April 15, 2009

• A population-average MRI-based atlas collection of the rhesus macaque

  March 1, 2009

• Neurophysiology of swallowing: effects of age and bolus type

  February 1, 2009

• The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory

  February 1, 2009

• A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women

  January 1, 2009

• Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging

  August 15, 2008

• Effect of parental family history of Alzheimer's disease on serial position profiles

  July 1, 2008

• Atorvastatin Therapy is Associated with Greater and Faster Cerebral Hemodynamic Response

  June 1, 2008

• Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review

  May 1, 2008

• Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial

  March 1, 2008

• Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease

  March 1, 2008

• Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment

  March 1, 2008

• fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's disease

  December 17, 2007

• Brain mapping in cognitive disorders: a multidisciplinary approach to learning the tools and applications of functional neuroimaging

  October 22, 2007

• Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults

  October 1, 2007

• Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma

  May 1, 2007

• Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal

  May 1, 2007

• The Relationship Between Gray Matter Morphometry and Neuropsychological Performance in a Large Sample of Cognitively Healthy Adults.

  January 1, 2007

• Relevance to self: A brief review and framework of neural systems underlying appraisal

  January 1, 2007

• Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation

  December 12, 2006

• Neural correlates of self-evaluative accuracy after traumatic brain injury

  September 8, 2006

• Network analysis of single-subject fMRI during a finger opposition task

  August 1, 2006

• Relationship of cognitive measures and gray and white matter in Alzheimer's disease

  August 1, 2006

• Computational models of the hippocampal region: implications for prediction of risk for Alzheimer's disease in non-demented elderly

  July 1, 2006

• The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation

  May 31, 2006

• Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networks

  April 15, 2006

• Application of Brodmann's area templates for ROI selection in white matter tractography studies

  February 1, 2006

• Task-dependent posterior cingulate activation in mild cognitive impairment

  January 15, 2006

• Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study

  January 13, 2006

• Structural MRI discriminates individuals with Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel based morphometry study.

  January 1, 2006

• The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study

  December 2, 2005

• The cerebral response during subjective choice with and without self-reference

  December 1, 2005

• Functional MRI neuroanatomic correlates of the Hooper Visual Organization Test

  November 1, 2004

• Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matter

  September 1, 2004

• Metacognitive evaluation, self-relevance, and the right prefrontal cortex

  June 1, 2004

• Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairment

  January 1, 2004

• Functional MRI and Wada determination of language lateralization: a case of crossed dominance

  January 1, 2004

• Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease

  November 1, 2003

• Neural correlates of self-reflection

  August 1, 2002