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Fall 2010, 3 credits
Seminar Leader: Sterling C. Johnson, PhD
TA: Aadhavi Sridharan
CSC G5/113 (see schedule for occasional changes)
Tuesday 2:30 to 3:50 PM
Thursday 2:30 to 3:50 PM
Faculty lecture followed by 20 minutes of discussion/student presentations on journal articles.
This seminar course is about the application of cutting edge brain imaging methods to understanding clinical disorders and brain function. Several clinical problems in neuroscience will be studied, such as the effect of disease (e.g. neurodegenerative diseases, stroke, brain injury, epilepsy), psychiatric disorders (e.g. anxiety or depression) or current mental or physical state (e.g. stress or pain) on brain function and structure.
Brain mapping in clinical disorders requires a multidisciplinary approach. The faculty for this seminar represent multiple disciplines who each bring an important knowledge-base and perspective on clinical and/or methodological issues pertaining to the topic. Following the presentation, there will be a student-led discussion on a relevant paper.
(available at the UW Bookstore)
Mid Term Exam (20%): The midterm will consist of multiple choice and short answer questions related to methodological concepts and issues from the first half of the course.
Student Presentation (16%):
Each student will select and present a paper to the class. A list of potential research papers will be provided. Students may select other papers with instructor approval.
Final Paper (50%):
This is an opportunity to integrate the knowledge you have gained in the course. Design a research protocol for a neuroimaging study in a clinical population. The paper should be roughly 20-30 double spaced pages in length and should include sections on the following:
A) Topic background, review of constructs, and summary of the literature leading to the proposed study;
B) Specific hypotheses that will be addressed by your study;
B) Methods describing group characteristics and inclusion and exclusion criteria;
C) Imaging acquisition procedures in detail and justification of why particular parameters were selected from all the possible reasonable choices;
D) Detailed description and justification of image processing and analytical procedures chosen to address your hypotheses;
E) Expected results; and
F) Discussion of Limitations and Alternative Approaches.
Because the main feature of the class is the seminar lecture series from UW Faculty, your attendance at the seminar is essential to the success of the course. Be familiar with the readings for the day and be prepared to interact with the speakers. Half a point per attended session is given (for a maximum of 14 points for the 28 class sessions).
|Date||Lecture Topic||Faculty Lecturer||Location|
|9/2/2010||Introduction to Functional Brain Mapping in Brain Disorders||Sterling C. Johnson, PhD||G5/113|
|9/7/2010||MRI Image Formation||Beth Meyerand, PhD||G5/113|
|9/9/2010||PET Image Formation and Applications||Brad Christian, PhD||G5/113|
|9/14/2010||Intro to fMRI Concepts||S. Johnson, PhD||G5/113|
|9/16/2010||Image and Data Analysis 1||John Ollinger, PhD||E5/492|
|9/21/2010||AFNI software intro and fMRI analysis||Rasmus Birn, PhD||K6/120|
|9/23/2010||Analysis with AFNI and research applications||Rasmus Birn, PhD||G5/113|
|9/28/2010||Image and Data Analysis 2||John Ollinger, PhD||G5/113|
|9/30/2010||Brain Connectivity||Rasmus Birn, PhD||G5/113|
|10/5/2010||Working memory measured with fMRI, TMS, EEG||Brad Postle, PhD||G5/113|
|10/7/2010||DTI and theory and applications||Andy Alexander, PhD||G5/113|
|10/12/2010||White matter imaging and demyelinating disease||Aaron Field, MD/PhD||G5/113|
|10/14/2010||Cognition, aging and brain white matter||Barb Bendlin, PhD||G5/113|
|10/19/2010||Alzheimer’s disease: mapping preclinical changes||S. Johnson, PhD||K6/120|
|10/21/2010||Machine learning approaches to brain mapping: AD classification||Vikas Singh, PhD||G5/152|
|10/26/2010||Cerebral blood flow with ASL||Guofan Xu, MD/PhD||G5/113|
|10/28/2010||The lesion method in human cognitive neuroscience||Mike Koenigs, PhD||G5/113|
|11/2/2010||Cognitive Mapping in the Brain Utilizing fMRI and Stroke Imaging||Vivek Prabhakaran, MD/PhD||G5/113|
|11/4/2010||Stroke and perfusion imaging||Howard Rowley, MD||G5/113|
|11/9/2010||Mapping dopamine loss in Parkinson’s disease||Cathy Gallagher, MD||G5/113|
|11/11/2010||Epilepsy||Bruce Hermann, PhD||G5/113|
|11/18/2010||Student paper presentations||G5/152|
|11/23/2010||Pain||Dane Cook, PhD||G5/113|
|11/30/2010||Neural correlates of olfactory perception||Wen Li, PhD||G5/113|
|12/2/2010||fMRI of swallowing and motor plasticity||JoAnne Robbins, PhD||G5/152|
|12/7/2010||Student paper presentations||G5/113|
|12/9/2010||Stress hormones and emotional memory in depression||Heather Abercrombie, PhD||G5/113|
|12/14/2010||Anxiety and Depression||Jack Nitschke, PhD||G5/113|