Clinically Oriented Objectives:

  • Detect AD pathology in the preclinical phase of disease
  • Identify AD-related cognitive changes that are separable from normal aging
  • In people who have biomarker evidence of preclinical AD, predict with greater certainty who will progress to dementia and when
  • Characterize large scale brain functional and structural patterns that may be associated with cognitive outcomes and the role of individual differences in risk and resilience characteristics
  • Identify modifiable factors that may prevent or slow the onset of AD dementia including lifestyle behaviors such as diet, physical activity, cognitive activity, and sleep
  • Develop imaging markers as potential outcome measures that can be applied to prevention and treatment trials

Cognitive Neuroscience Objectives:

  • Identifying neural systems involved in memory encoding and retrieval
  • Understand how tau and amyloid burden affect brain function and connectivity
  • Develop new methods for detecting subtle cognitive and brain dysfunction that represent the early manifestation of AD