Clinically Oriented Objectives:

  • Detect preclinical brain changes in Alzheimer Disease that are separable from normal aging
  • Characterize large scale brain functional and structural patterns that may be associated with outcomes such as compensation or cognitive decline in neurological disorders
  • Predict with greater certainty who will progress to dementia
  • Support ADRC clinical and translational research in aging and dementia including development of imaging markers as outcomes in treatment trials

Cognitive Neuroscience Objectives:

  • Identifying neural systems involved in memory encoding and retrieval
  • Clarify the role of self-relevance and salience systems in memory formation
  • Understand how risk factors for Alzheimer Disease affect brain function
  • Uncover age-related changes in brain structure and function